{"id":3393,"date":"2025-03-17T15:35:35","date_gmt":"2025-03-17T14:35:35","guid":{"rendered":"https:\/\/triton.iplesp.upmc.fr\/hepather_ANRS\/?p=3393"},"modified":"2025-03-17T15:39:58","modified_gmt":"2025-03-17T14:39:58","slug":"2024-une-annee-de-preparation-et-de-transition-3-publications-par-lequipe-du-sesstim","status":"publish","type":"post","link":"https:\/\/triton.iplesp.upmc.fr\/hepather_ANRS\/2024-une-annee-de-preparation-et-de-transition-3-publications-par-lequipe-du-sesstim\/","title":{"rendered":"2024 – une ann\u00e9e de pr\u00e9paration et de transition. 3 publications par l’\u00e9quipe du SESSTIM."},"content":{"rendered":"\n

L’ann\u00e9e 2024 a \u00e9t\u00e9 marqu\u00e9e par la pr\u00e9paration de la suite de la cohorte HEPATHER dont la date de fin \u00e9tait programm\u00e9e au 31 d\u00e9cembre 2024.
Hepat-B proposera de prolonger le suivi des patients atteints d’h\u00e9patite B inclus dans Hepather jusqu’en 2029, avec la r\u00e9alisation de nouvelles collections biologiques. Cette cohorte est particuli\u00e8rement pertinente \u00e0 l’aune de l’arriv\u00e9e de nouvelles strat\u00e9gies th\u00e9rapeutiques de l’h\u00e9patite B. Pour les patients atteints d’h\u00e9patite C inclus dans Hepather, le suivi dans la cohorte s’arr\u00eate au 31 d\u00e9cembre 2024, mais les \u00e9tudes valorisant les donn\u00e9es collect\u00e9es dans la cohorte ou exploitant celles du SNDS continuent !
La cohorte Hepat-B est soutenue par l’ANRS-MIE et devrait \u00eatre install\u00e9e en 2025.

Au cours de l’ann\u00e9e 2024, trois travaux importants (qui devraient \u00eatre publi\u00e9s en 2025) ont \u00e9t\u00e9 r\u00e9alis\u00e9s chez les patients atteints d’h\u00e9patite B. Ils ont sp\u00e9cifiquement port\u00e9
1)<\/strong> sur les risques de complications h\u00e9patiques et de mise sous traitement des patients dits dans la \u00ab\u00a0zone grise\u00a0\u00bb – c.a.d. ayant une charge virale B sup\u00e9rieure \u00e0 2000 Unit\u00e9s\/mL mais inf\u00e9rieure \u00e0 20 000 Unit\u00e9s \/ mL ou ayant des transminases h\u00e9patiques sup\u00e9rieure \u00e0 la limite normale sup\u00e9rieure mais inf\u00e9rieure \u00e0 2 fois cette limite sup\u00e9rieure. Les analyses qui portaient sur 746 patient de la cohorte hepather montre que le risque de cancer du foie, de d\u00e9compensation de cirrhose sont de m\u00eame ordre que ceux observ\u00e9s chez les patients avec infection chronique HBe- et non diff\u00e9rents de ceux de la population g\u00e9n\u00e9rale de m\u00eame \u00e2ge et sexe. En revanche, chez ces sujets de la \u00ab\u00a0zone grise\u00a0\u00bb, la chance d’une n\u00e9gativation de l’antig\u00e8ne HBs (marqueur de gu\u00e9rison fonctionnelle de l’h\u00e9patite B) restait plus faible.
2)<\/strong> la caract\u00e9risation et le pronostique des patients co\/sur-infect\u00e9s par le virus Delta en plus du virus B compar\u00e9 \u00e0 des patients monoinfect\u00e9s par le virus B. Un travail exploratoire montre la gravit\u00e9 plus importante de la maladie h\u00e9patique chez ces patients Delta.
3)<\/strong> l’\u00e9valuation du suivi par imagerie pour le d\u00e9pistage de carcinome h\u00e9patocellulaire chez les patients avec fibrose avanc\u00e9 et\/ou score de PAGE-B sup\u00e9rieur ou \u00e9gal \u00e0 10. Ce travail montre la pertinence de ce d\u00e9pistage chez les patients avec fibrose avanc\u00e9, mais ne justifie pas la r\u00e9alisation de celui-ci chez les patients avec score de PAGE-B sup\u00e9rieur ou \u00e9gal \u00e0 10 qui n’ont pas de fibrose avanc\u00e9e.
Ces travaux ont fait l’objet de pr\u00e9sentations lors du congr\u00e8s de l’AFEF, et \u00e0 l’AASDL (congr\u00e8s am\u00e9ricain des maladies du foie) en 2024.<\/p>\n\n\n\n

Les 3 publications de 2024 portent sur les modifications avant et apr\u00e8s traitement par antiviraux directs de la qualit\u00e9 de vie explor\u00e9e dans 8 dimensions gr\u00e2ce \u00e0 l’outil PRO-QOL 1<\/strong><\/sup>, et deux travaux sur l’impact de la vuln\u00e9rabilit\u00e9 sociale ou de la consommation de drogues par voie intraveineuse sur l’\u00e9volution de la maladie h\u00e9patique apr\u00e8s traitement de l’h\u00e9patite C. 23<\/sup><\/strong>

1<\/strong> Abbas M, Patrizia C, Fabienne M, et al. Minimal clinically important differences in health-related quality of life after treatment with direct-acting antivirals for chronic hepatitis C: ANRS CO22 HEPATHER cohort (PROQOL-HCV). Qual Life Res 2024; 33: 1527\u201340.

2<\/strong> Barr\u00e9 T, Bourli\u00e8re M, Parlati L, et al. Hepatitis C virus cure from direct-acting antivirals and mortality: Are people with and without a history of injection drug use in the same boat? (ANRS CO22 Hepather cohort). Drug Alcohol Rev 2024; 43: 718\u201331.

3<\/strong> Barr\u00e9 T, Parlati L, Bourli\u00e8re M, et al. Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22\u00a0Hepather). J Viral Hepat 2024; 31: 830\u201346.<\/p>\n","protected":false},"excerpt":{"rendered":"

L’ann\u00e9e 2024 a \u00e9t\u00e9 marqu\u00e9e par la pr\u00e9paration de la suite de la cohorte HEPATHER dont la date de fin \u00e9tait programm\u00e9e au 31 d\u00e9cembre 2024.Hepat-B proposera de prolonger le suivi des patients atteints d’h\u00e9patite B inclus dans Hepather jusqu’en 2029, avec la r\u00e9alisation de nouvelles collections biologiques. Cette cohorte est particuli\u00e8rement pertinente \u00e0 l’aune […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-3393","post","type-post","status-publish","format-standard","hentry","category-actualites"],"yoast_head":"\n2024 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De Ledinghen V & al. J Viral Hepat. 2020 Oct;27(10):964-973. doi: 10.1111\/jvh.13321. 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